The neurophysiology of intersensory selective attention and task switching

Our ability to selectively attend to certain aspects of the world and ignore others is fundamental to our day-to-day lives. The need for selective attention stems from capacity limitations inherent in our perceptual and cognitive processing architecture. Because not every elemental piece of our environment can be fully processed in parallel, the nervous system must prioritize processing. This prioritization is generally referred to as selective attention. Meanwhile, we are faced with a world that is constantly in flux, such that we have to frequently shift our attention from one piece of the environment to another and from one task to another. This process is generally referred to as task-switching. Neural oscillations in the alpha band (~8-14 Hz) have been shown to index the distribution of selective attention, and there is increasing evidence that oscillations in this band are in fact utilized by the nervous system to suppress distracting, task-irrelevant information. In order to elaborate on what is known of the function of alpha oscillations as well as current models of both intersensory selective attention and task switching, I investigated the dynamics of alpha amplitude modulations within the context of intersenory selective attention and task switching in neurologically typical young adults. Participants were alternately cued to attend to either the visual or auditory aspect of a compound audio-visual stimulus while high-density electroencephalography was recorded. It is typically found that alpha power increases over parieto-occipital cortices when attention is directed away from the visual modality and to the auditory modality. I report evidence that alpha oscillations play a role in task-switching (e.g., when switching from attending the visual task versus repeating this task), specifically as biasing signals, that may operate to re-weight competition among two tasks-sets. I further investigated the development of these same processes in school-aged children and adolescents. While exhibiting typical patterns of alpha modulations relevant to selective attention, Young school-aged children (8-12 years), compared to older participants, did not demonstrate specific task switching modulation of alpha oscillations, suggesting that this process does not fully develop until late adolescence. Finally, children and adolescents on the autism spectrum failed altogether to exhibit differentiation of alpha power between attend-visual and attend-auditory conditions--an effect present in age and IQ matched controls--suggesting that ASD individuals may have a deficit in the overall top-down deployment of alpha oscillatory biasing signals. This could result in an inability to ignore distracting information in the environment, leading to an overwhelming, disordered experience of the world, resulting in profound effects on the both social interaction and cognitive development. Altogether, these findings add to growing evidence that alpha oscillations serve as domain general biasing signals and are integral to our flexible goal-oriented behavior. Furthermore, the flexible use of these biasing signals in selective attention and task switching develops over a protracted period, and appears to be aberrant in autism spectrum disorder

The Effects of Completing PREP Academy: A University-Based Transition Project for Students with Disabilities (Practice Brief)

This practice brief provides an overview of a project designed to support students with disabilities considering postsecondary education. Postsecondary Rewarding Education is Possible (PREP) Academy was developed by individuals from a state vocational rehabilitation agency and a public research university. PREP Academy is a campus-based, weeklong experience in which students participate in activities designed to mirror the “college experience.” In an evaluation of the project’s second year, a total of 23 students and six parents/guardians completed a pre- and post-survey to examine how attending the project affected students’ perceptions related to students attending college. Interview data from three student and parent/guardian pairs were collected to further explore students’ perceptions and to learn what components of the project were most beneficial. Results provided evidence both students and parents/guardians believe students are better prepared to attend college after participating. An emerging theme related to increasing the project’s emphasis on mirroring aspects of college was identified

Two-Component Fokker-Planck Models for the Evolution of Isolated Globular Clusters

Two-component (normal and degenerate stars) models are the simplest realization of clusters with a mass spectrum because high mass stars evolve quickly into degenerates, while low mass stars remain on the main-sequence for the age of the universe. Here we examine the evolution of isolated globular clusters using two-component Fokker-Planck (FP) models that include heating by binaries formed in tidal capture and in three-body encounters. Three-body binary heating dominates and the postcollapse expansion is self-similar, at least in models with total mass M <= 3 x 10^5 M_\odot, initial half-mass radius r_{h,i} >= 5 pc, component mass ratio m_2/m_1 <= 2, and number ratio N_1/N_2 <= 300 when m_2=1.4 M_\odot. We derive scaling laws for \rho_c, v_c, r_c, and r_h as functions of m_1/m_2, N, M, and time t from simple energy-balance arguments, and these agree well with the FP simulations. We have studied the conditions under which gravothermal oscillations (GTOs) occur. If E_{tot} and E_c are the energies of the cluster and of the core, respectively, and t_{rh} and t_c are their relaxation times, then \epsilon \equiv (E_{tot}/t_{rh})/(E_c/t_{rc}) is a good predictor of GTOs: all models with \epsilon>0.01 are stable, and all but one with \epsilon < 0.01 oscillate. We derive a scaling law for \epsilon against N and m_1/m_2 and compared with our numerical results. Clusters with larger m_2/m_1 or smaller N are stabler.Comment: 15 pages (LaTeX) with 8 figures. To appear in ApJ March 10, 1998 issu

Batf3-Dependent CD11blow/− Peripheral Dendritic Cells Are GM-CSF-Independent and Are Not Required for Th Cell Priming after Subcutaneous Immunization

Dendritic cells (DCs) subsets differ in precursor cell of origin, functional properties, requirements for growth factors, and dependence on transcription factors. Lymphoid-tissue resident CD8α+ conventional DCs (cDCs) and CD11blow/−CD103+ non-lymphoid DCs are developmentally related, each being dependent on FMS-like tyrosine kinase 3 ligand (Flt3L), and requiring the transcription factors Batf3, Irf8, and Id2 for development. It was recently suggested that granulocyte/macrophage colony stimulating factor (GM-CSF) was required for the development of dermal CD11blow/−Langerin+CD103+ DCs, and that this dermal DC subset was required for priming autoreactive T cells in experimental autoimmune encephalitis (EAE). Here, we compared development of peripheral tissue DCs and susceptibility to EAE in GM-CSF receptor deficient (Csf2rb−/−) and Batf3−/− mice. We find that Batf3-dependent dermal CD11blow/−Langerin+ DCs do develop in Csf2rb−/− mice, but that they express reduced, but not absent, levels of CD103. Further, Batf3−/− mice lacking all peripheral CD11blow/− DCs show robust Th cell priming after subcutaneous immunization and are susceptible to EAE. Our results suggest that defective T effector priming and resistance to EAE exhibited by Csf2rb−/− mice does not result from the absence of dermal CD11blow/−Langerin+CD103+ DCs

The effect of coordination of alkanes, Xe and CO2 (η1-OCO) on changes in spin state and reactivity in organometallic chemistry: a combined experimental and theoretical study of the photochemistry of CpMn(CO)3

A combined experimental and theoretical study is presented of several ligand addition reactions of the triplet fragment 3CpMn(CO)2 formed upon photolysis of CpMn(CO)3. Experimental data are provided for reactions in n-heptane and perfluoromethylcyclohexane (PFMCH), as well as in PFMCH doped with C2H6, Xe and CO2. In PFMCH we find that the conversion of 3CpMn(CO)2 to 1CpMn(CO)2(PFMCH) is much slower (τ = 18 (±3) ns) than the corresponding reactions in conventional alkanes (τ = 111 (±10) ps). We measure the effect of the coordination ability by doping PFMCH with alkane, Xe and CO2; these doped ligands form the corresponding singlet adducts with significantly variable formation rates. The reactivity as measured by the addition timescale follows the order 1CpMn(CO)2(C5H10) (τ = 270 (±10) ps) > 1CpMn(CO)2Xe (τ = 3.9 (±0.4) ns) ∼ 1CpMn(CO)2(CO2) (τ = 4.7 (±0.5) ns) > 1CpMn(CO)2(C7F14) (τ = 18 (±3) ns). Electronic structure theory calculations of the singlet and triplet potential energy surfaces and of their intersections, together with non-adiabatic statistical rate theory, reproduce the observed rates semi-quantitatively. It is shown that triplet adducts of the ligand and 3CpMn(CO)2 play a role in the kinetics, and account for the variable timescales observed experimentally

Angiosperm symbioses with non-mycorrhizal fungal partners enhance N acquisition from ancient organic matter in a warming maritime Antarctic

In contrast to the situation in plants inhabiting most of the world’s ecosystems, mycorrhizal fungi are usually absent from roots of the only two native vascular plant species of maritime Antarctica, Deschampsia antarctica and Colobanthus quitensis. Instead, a range of ascomycete fungi, termed dark septate endophytes (DSEs), frequently colonise the roots of these plant species. We demonstrate that colonisation of Antarctic vascular plants by DSEs facilitates not only the acquisition of organic nitrogen as early protein breakdown products, but also as non-proteinaceous D-amino acids and their short peptides, accumulated in slowly-decomposing organic matter, such as moss peat. Our findings suggest that, in a warming maritime Antarctic, this symbiosis has a key role in accelerating the replacement of formerly dominant moss communities by vascular plants, and in increasing the rate at which ancient carbon stores laid down as moss peat over centuries or millennia are returned to the atmosphere as CO2.Additional co-authors: Richard D Bardgett, David W Hopkins and Davey L Jone

Between-Monitor Differences in Step Counts Are Related to Body Size: Implications for Objective Physical Activity Measurement

The quantification of the relationships between walking and health requires that walking is measured accurately. We correlated different measures of step accumulation to body size, overall physical activity level, and glucose regulation.Participants were 25 men and 25 women American Indians without diabetes (Age: 20-34 years) in Phoenix, Arizona, USA. We assessed steps/day during 7 days of free living, simultaneously with three different monitors (Accusplit-AX120, MTI-ActiGraph, and Dynastream-AMP). We assessed total physical activity during free-living with doubly labeled water combined with resting metabolic rate measured by expired gas indirect calorimetry. Glucose tolerance was determined during an oral glucose tolerance test.Based on observed counts in the laboratory, the AMP was the most accurate device, followed by the MTI and the AX120, respectively. The estimated energy cost of 1000 steps per day was lower in the AX120 than the MTI or AMP. The correlation between AX120-assessed steps/day and waist circumference was significantly higher than the correlation between AMP steps and waist circumference. The difference in steps per day between the AX120 and both the AMP and the MTI were significantly related to waist circumference.Between-monitor differences in step counts influence the observed relationship between walking and obesity-related traits

Where do stars explode in the ISM? -- The distribution of dense gas around massive stars and supernova remnants in M33

Star formation in galaxies is regulated by turbulence, outflows, gas heating and cloud dispersal -- processes which depend sensitively on the properties of the interstellar medium (ISM) into which supernovae (SNe) explode. Unfortunately, direct measurements of ISM environments around SNe remain scarce, as SNe are rare and often distant. Here we demonstrate a new approach: mapping the ISM around the massive stars that are soon to explode. This provides a much larger census of explosion sites than possible with only SNe, and allows comparison with sensitive, high-resolution maps of the atomic and molecular gas from the Jansky VLA and ALMA. In the well-resolved Local Group spiral M33, we specifically observe the environments of red supergiants (RSGs, progenitors of Type II SNe), Wolf-Rayet stars (WRs, tracing stars $>$30 M$_{\odot}$, and possibly future stripped-envelope SNe), and supernova remnants (SNRs, locations where SNe have exploded). We find that massive stars evolve not only in dense, molecular-dominated gas (with younger stars in denser gas), but also a substantial fraction ($\sim$45\% of WRs; higher for RSGs) evolve in lower-density, atomic-gas-dominated, inter-cloud media. We show that these measurements are consistent with expectations from different stellar-age tracer maps, and can be useful for validating SN feedback models in numerical simulations of galaxies. Along with the discovery of a 20-pc diameter molecular gas cavity around a WR, these findings re-emphasize the importance of pre-SN/correlated-SN feedback evacuating the dense gas around massive stars before explosion, and the need for high-resolution (down to pc-scale) surveys of the multi-phase ISM in nearby galaxies.Comment: 34 pages, 14 figures. Submitted to ApJ. Comments welcome! The density distributions will be made publicly available after journal acceptance of manuscript. Please feel free to contact us in the meantime if you would like to use the